Mini-review: A possible role for galanin in post-traumatic stress disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG42__%2F21%3A00556977" target="_blank" >RIV/60162694:G42__/21:00556977 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S030439402100358X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S030439402100358X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2021.135980" target="_blank" >10.1016/j.neulet.2021.135980</a>

Result language

angličtina

Original language name

Mini-review: A possible role for galanin in post-traumatic stress disorder

Original language description

Several neuroendocrine systems have been implicated in post-traumatic stress disorder, including the meso-cortical and mesolimbic dopamine, the norepinephrine, the beta-endorphin, the serotonin, and the oxytocin systems. The interaction between these different systems remains, however, largely unknown and a generally accepted unifying theory is thus far lacking. In this review, we suggest that galanergic suppression of dopami-nergic neurons in the ventral tegmental may constitute the missing link in a post-traumatic feedback loop. In addition, we address the literature on the negative cross-antagonism in this brain region between the galanin 1 and mu-opioid receptors, which suggests that behavioural patterns which stimulate beta-endorphin, a natural mu-opioid receptors ligand, secretion may provide novel avenues for the treatment and prevention of PTSD, as well as for recruitment, training, and leadership processes in high-stress/high-risk professions such as the military, first responders and the police.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NEUROSCIENCE LETTERS

ISSN

0304-3940

e-ISSN

1872-7972

Volume of the periodical

756

Issue of the periodical within the volume

1

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

135980

UT code for WoS article

000657100800002

EID of the result in the Scopus database

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