Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001237" target="_blank" >RIV/60162694:G44__/05:00001237 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats

Original language description

The present study was performed to assess and compare a therapeutic efficacy of obidoxime, HI-6, BI-6 and HS-6 administered in equimolar doses and combined with atropine in cyclosarin-poisoned mice and rats. It was demonstrated that all the therapeutic regimens tested, were able to decrease the cyclosarin-induced toxicity significantly - at least 1.5 times. Higher therapeutic ratios, almost three times, were achieved in rats in comparison with mice. The highest therapeutic ratio was achieved for therapeutic regimen consisting of HI-6 and atropine in both mice and rats. Obidoxime was the least effective oxime in the treatment of cyclosarin intoxication. The BI-6 oxime was significantly more efficacious than obidoxime (in both mice and rats) and HS-6 (inrats) but its effectiveness did not reach the efficacy of HI-6.

Czech name

Účinnost nových reaktivátorů acetylcholinesterázy v léčbě otrav cyklosarinem u myší a potkanů

Czech description

Studie by la prováděna pro zjištění a srovnání terapeutické účinnosti obidoximu, HI-6, BI-6 a HS-6 podávaných v kombinaci s atropinem. Sledována účinnost nových reaktivátorů acetylcholinesterázy v léčbě otrav cyklosarinem u myší a potkanů.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

149

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

425-427

UT code for WoS article

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EID of the result in the Scopus database

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