Bispyridinium oximes as antidotal treatment of cyclosarin poisoning - in vitro and in vivo testing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001236" target="_blank" >RIV/60162694:G44__/05:00001236 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Bispyridinium oximes as antidotal treatment of cyclosarin poisoning - in vitro and in vivo testing
Original language description
The mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents and less toxic pesticides, is based on the formation of irreversibly inhibited acetylcholinesterase, which causes cumulation of neuromediator acetylcholinein synaptic clefts and subsequent overstimulation of cholinergic receptors, that is followed by a generalized cholinergic crisis. Nerve agent poisoning is conventionally treated using a combination of a cholinolytic (atropine mostly) to counteract the accumulation of acetylcholine and acetylcholinesterase reactivators (pralidoxime or obidoxime) to reactivate inhibited acetylcholinesterase. In this study of cyclosarin poisoning treatment, oximes of different chemical structures (obidoxime, HI-6, BI-6, and HS-6) were tested in vitro on rat brain acetylcholinesterase (enzyme source: rat brain homogenate), and afterwards, they were tested in vivo in equimolar doses, in mice and rats. The HI-6 oxime appeared to be the most effective oxime i
Czech name
In vitro a in vivo testování bispyridiniových oximů při terapii otrav cyklosarinem
Czech description
Mechanismus intoxikace organofosfáty zahrnujícími vysoce toxické NPL a pesticidy je založen na formaci irevirzibilně inhibované acetylcholinesterázy. In vitro a in vivo byly testovány bispyridiniové oximy při terapii otrav cyklosarinem.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Toxicology
ISSN
1091-5818
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
399-402
UT code for WoS article
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EID of the result in the Scopus database
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