In vitro reactivation potency of some acetylcholinesterase reactivators against sarin and cyclosarin-induced inhibitions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001307" target="_blank" >RIV/60162694:G44__/05:00001307 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
In vitro reactivation potency of some acetylcholinesterase reactivators against sarin and cyclosarin-induced inhibitions
Original language description
In our study, we have tested six acetylcholinesterase (AChE) reactivators - pralidoxime, obidoxime, HI-6, trimedoxime, BI-6, and Hlö-7 - for reactivation of sarin and cyclosarin inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin-inhibited AChE. On the other hand, only HI-6 is able satisfactorily to reactivate cyclosarin-inhibited AChE.
Czech name
In vitro reaktivační schopnost několika reaktivátorů AChE při inhibicích sarinem a cyklosarinem
Czech description
In vitro reaktivační schopnost několika reaktivátorů AChE při inhibicích sarinem a cyklosarinem.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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