Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin-nerve agent
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001305" target="_blank" >RIV/60162694:G44__/05:00001305 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin-nerve agent
Original language description
In this work in vitro evaluation of the reactivation potency of the newly synthesized reactivators for acetylcholinesterase (AChE; EC 3.1.1.7) is described.Using this method, reactivation potency of twenty-one potential reactivators of AChE inhibited bynerve agent - sarin has been evaluated. We have confirmed the fact that currently the most promising AChE-reactivator HI-6 is the most effective reactivator of sarin-inhibited AChE. There are only three AChE reactivators - HI-6, TO033 and TO047 able to satisfactorily reactivate sarin-inhibited AChE at the concentration 10-5 M, which is non-toxic for human use. On the other hand, there are fourteen AChE reactivators, which are able to reactivate sarin-inhibited AChE at the concentration 10-3 M. However,this concentration of reactivator is probably toxic for human use.
Czech name
Hodnocení nově syntetizovaných reaktivátorů cholinesterázy inhibovyné NPL sarinem
Czech description
Hodnocení nově syntetizovaných reaktivátorů cholinesterázy inhibovyné NPL sarinem.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Mechanisms and Methods
ISSN
1537-6524
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
247-252
UT code for WoS article
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EID of the result in the Scopus database
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