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Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin-nerve agent

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001305" target="_blank" >RIV/60162694:G44__/05:00001305 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin-nerve agent

  • Original language description

    In this work in vitro evaluation of the reactivation potency of the newly synthesized reactivators for acetylcholinesterase (AChE; EC 3.1.1.7) is described.Using this method, reactivation potency of twenty-one potential reactivators of AChE inhibited bynerve agent - sarin has been evaluated. We have confirmed the fact that currently the most promising AChE-reactivator HI-6 is the most effective reactivator of sarin-inhibited AChE. There are only three AChE reactivators - HI-6, TO033 and TO047 able to satisfactorily reactivate sarin-inhibited AChE at the concentration 10-5 M, which is non-toxic for human use. On the other hand, there are fourteen AChE reactivators, which are able to reactivate sarin-inhibited AChE at the concentration 10-3 M. However,this concentration of reactivator is probably toxic for human use.

  • Czech name

    Hodnocení nově syntetizovaných reaktivátorů cholinesterázy inhibovyné NPL sarinem

  • Czech description

    Hodnocení nově syntetizovaných reaktivátorů cholinesterázy inhibovyné NPL sarinem.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology Mechanisms and Methods

  • ISSN

    1537-6524

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    247-252

  • UT code for WoS article

  • EID of the result in the Scopus database