A comparison of in vitro potency of currently available oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001311" target="_blank" >RIV/60162694:G44__/05:00001311 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A comparison of in vitro potency of currently available oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

Original language description

A potency of currently used oximes to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain and the whole pig brain was evaluated using in vitro methods. Significant differences in reactivation potency among all tested oximes wereobserved. At concentration (10-4 M) corresponding to recommended doses in vivo, the oxime HI-6 seems to be more efficacious reactivator of sarin-inhibited AChE in the whole pig brain as well as in cerebral hemispheres and cerebellum compared to other oximes studied. Nevertheless, there are not any differences in the potency of oximes tested to reactivate sarin-inhibited AChE in medulla oblongata. Thus, the oxime HI-6 appears to be the most promising oxime among currently available oximes for the antidotal treatment of acute sarin poisonings although it is not more efficacious than other currently used oximes in medulla oblongata whose function is necessary for vital functions - respiration and circulation.

Czech name

Srovnávání in vitro schopnosti současně užívaných oximů (pralidoximu, obidoximu, HI-6) v reaktivaci sarinem inhibované acetylcholinesterázy v rozličných částech prasečího mozku

Czech description

Srovnávání in vitro schopnosti současně užívaných oximů (pralidoximu, obidoximu, HI-6) v reaktivaci sarinem inhibované acetylcholinesterázy v rozličných částech prasečího mozku.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Toxicology

ISSN

0260-437X

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

271-276

UT code for WoS article

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EID of the result in the Scopus database

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