Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001289" target="_blank" >RIV/60162694:G44__/05:00001289 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species
Original language description
The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. The results demonstrate remarkable differences in the reactivation of inhibited brain AChE, depending on the oxime and species.
Czech name
Porovnání schopnosti vybraných oximů reaktivovat sarinem inhibovanou mozkovou acetylcholinesterázu z různých živočišných druhů
Czech description
Hlavním cílem práce bylo porovnání schopnosti vybraných oximů reaktivovat sarinem inhibovanou mozkovou acetylcholinesterázu z různých živočišných druhů.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemico-Biological Interactions
ISSN
0009-2797
e-ISSN
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Volume of the periodical
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Issue of the periodical within the volume
157-158
Country of publishing house
IE - IRELAND
Number of pages
3
Pages from-to
385-387
UT code for WoS article
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EID of the result in the Scopus database
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