Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001490" target="_blank" >RIV/60162694:G44__/06:00001490 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases

Original language description

Antidotes currently used in the case of organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Owing to the wide-spread of these compounds worldwide, development of antidotes for the case of the first aid is needed. To select the most promising AChE reactivators is very time consuming process, which is necessary before approval of these compounds to be used as human antidotes. Becauseof ethical reasons, many developing experiments have been conducted on laboratory animals. However, these results could not be often transferred directly to human. Due to this fact, in our work, we have tested five newly developed AChE reactivators # K027, K033, K048, K074 and K075, which achieved promising reactivation activity on rodents, as reactivators of human brain cholinesterases. For this purpose, cyclosarin was used as member of the nerve agent family. H-oxime HI-6 and pralidoxi

Czech name

Schopnost nových strukturně odlišných oximů reaktivovat cyclosarinem inhibovanou acetylcholinesterázu z lidského mozku

Czech description

Schopnost nově vyvinuých reaktivátorů acetylcholinesterázy (K027, K033, K048, K074 a K075) byla testována na cholinesterázách lidského mozku inhibovaných nervově paralytickou látkou cyklosarin.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Enzyme Inhibition and Medicinal Chemistry

ISSN

1475-6366

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

663-666

UT code for WoS article

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EID of the result in the Scopus database

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