Russian VX: Inhibition and reactivation of acetylcholinesterase and its comparison with VX-agent
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001492" target="_blank" >RIV/60162694:G44__/06:00001492 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Russian VX: Inhibition and reactivation of acetylcholinesterase and its comparison with VX-agent
Original language description
Organophosphorus compounds such as nerve agents inhibit, practically irreversible, cholinesterases (ChEs) by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent (NA) intoxications consists of combined administration of anticholinergic drug (usually atropine) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivator (HI-6, obidoxime, pralidoxime), which is from the chemical view a derivative from the group of pyridinium or bispyridinium aldoximes (commonly called #oxime#). Oximes counteract acetylcholine increase, resulting from AChE inhibition. These compounds are, in the conditions of human body environment, powerful nucleophiles and are able to break down the bond between AChE andNA molecule. This process leads to renew of enzyme functionality - to its reactivation. The usability of oxime in reactivation process depends on its chemical structure and on the NA agent whereby AChE was inhibited. Due to this fact, se
Czech name
Ruská VX: Inhibice a reaktivace acetylcholinesterazy a srovnávání s VX
Czech description
Byla srovnávány rozdíly v inhibici acetylcholinesterázy u dvou nervově paralytických látek # VX a ruská VX. Následně byla testována reaktivační schopnost pěti nejznámějších reaktivátorů AChE (pralidoxim, obidoxim, trimedoxim, methoxim a HI-6)
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Basic and Clinical Pharmacology and Toxicology
ISSN
1742-7835
e-ISSN
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Volume of the periodical
98
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
389-394
UT code for WoS article
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EID of the result in the Scopus database
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