Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002353" target="_blank" >RIV/60162694:G44__/10:00002353 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker
Original language description
Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH2O(CH2)(2)OCH2 and CH2O(CH2)(4)OCH2 were tested for their potency to reactivate VX-inhibited AChE. Their reactivation potency was compared with currently available oximes such as pralidoxime, obidoxime and HI-6. Appropriate constants (affinity towards the intact and inhibited enzyme, reactivation rate) characterizing the reactivation process were determined. According to the data obtained, a new oxime with CH2O(CH2)(2)OCH2 linker reached as high reactivation potency as HI-6. The percentage of reactivation of the oxime with CH2O(CH2)(2)OCH2 linker was comparable to that of obidoxime at a concentration 10 M. Hence, these oximes may be worthy of future development for the treatment of nerve agent intoxications, especially, with lipophilic agents such as soman and cyclosarin.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/OVUOFVZ200801" target="_blank" >OVUOFVZ200801: Robotized system for in vitro evaluation of novel rectivators of acetylcholinesterase inhibited by nerve agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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