Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001451" target="_blank" >RIV/60162694:G44__/06:00001451 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX

Original language description

New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

<a href="/en/project/ME%20865" target="_blank" >ME 865: Countermeasure against chemical terrorism - development of new antidotes against nerve agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic and Medicinal Chemistry Letters

ISSN

0960-894X

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

18

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

—

UT code for WoS article

000240395300032

EID of the result in the Scopus database

—