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Proteomic analysis of antibody response in a case of laboratory-acquired infection with Francisella tularensis subsp. tularensis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001729" target="_blank" >RIV/60162694:G44__/07:00001729 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Proteomic analysis of antibody response in a case of laboratory-acquired infection with Francisella tularensis subsp. tularensis

  • Original language description

    Immunoproteomic analysis was applied to study the immunoreactivity of serum samples collected at different time points from a laboratory assistant accidentally infected with highly virulent strain of Francisella tularensis subsp. tularensis. Immunoblotting showed that the spectrum of F. tularensis antigens recognized specifically by immune sera remained with the exception for 1 antigen stable for up to 16 years after infection. Using immunoproteomics approach 10 immunoreactive antigens were successfullyidentified. Several new immunogenic F. tularensis proteins were described for the first time.

  • Czech name

    Proteomová analýza protilátkové odpovědi u laboratorního pracovníka infikovaného subtypem Francisella tularensis subsp. tularensis

  • Czech description

    Imunoproteomová analýza byla použita ke studiu protilátkové specifity ve vzorcích séra získaných od laboratorních pracovníků náhodně infikovaných plně virulentním kmenem Francisella tularensis subsp. tularensis. Analýza vedla k identifikaci 10 různých imunoreaktivních antigenů, z nichž některé byly prokázány poprvé.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/OPUOFVZ200601" target="_blank" >OPUOFVZ200601: Crisis management after the use of biological agents</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Folia microbiologica

  • ISSN

    0015-5632

  • e-ISSN

  • Volume of the periodical

    52

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    194-198

  • UT code for WoS article

  • EID of the result in the Scopus database