Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001731" target="_blank" >RIV/60162694:G44__/07:00001731 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS

Original language description

Francisella tularensis is a Gram-negative, facultative intracellular bacterium causing disease in many mammalian species. The low infectious dose of F. tularensis and the ease of air-borne transmission are the main features responsible for the classification of this bacterium as a potential biological weapon. The live attenuated strain of F. tularensis live vaccine strain (LVS) is currently only effective vaccine against tularemia, however, this type of vaccine has not been approved for human use. In the presented study, sub-immunoproteome analysis was performed to search for new immunogenic proteins of Francisella tularensis LVS grown under different conditions. By this approach 35 immunoreactive antigens were identified, 19 of them showed to be novelimmunogens. In conclusion, sub-immunoproteome analysis resulted in successful identification of novel immunoreactive proteins.

Czech name

Identifikace imunoreaktivních antigenů mikroba Francisella tularensis LVS ve frakci obohacené o membránové proteiny

Czech description

V předložemé studii byly detekovány nové imunoreaktivní antigeny mikroba Francisella tularensis kultivovaného za různých podmínek. Tímtopostupem bylo identifikováno 35 antigenů, z nichž 19 bylo zcela nových.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/OPUOFVZ200601" target="_blank" >OPUOFVZ200601: Crisis management after the use of biological agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunology Letters

ISSN

0165-2478

e-ISSN

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Volume of the periodical

108

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

151-159

UT code for WoS article

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EID of the result in the Scopus database

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