TLC of quaternary pyridinium aldoximes, antidotes of organophosphorus esterase inhibitors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001808" target="_blank" >RIV/60162694:G44__/07:00001808 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
TLC of quaternary pyridinium aldoximes, antidotes of organophosphorus esterase inhibitors
Original language description
Quaternary pyridinium aldoximes have been analyzed by thin-layer chromatography. Their separation was adequate when silica plates were used with a mobile phase with a high water content. As a consequence of their limited migration, reversed-phase TLC wasnot appropriate for determination of the lipophilicity of quaternary pyridinium aldoximes. Displacement TLC of some quaternary pyridinium aldoximes is, nevertheless, possible using silica as stationary phase with water-acetone-hydrochloric acid mobile phases. Normal-phase TLC with different concentrations of organic modifier gave a series of R M values for the pyridinium aldoximes. Approximation of the different plots of R M against organic modifier concentration to straight lines afforded R M,0 valuesand the slopes of the lines. The R M,0 values and the slopes both serve as indicators of the hydrophilic character of the compounds.
Czech name
TLC kvarternich pyridiniových aldoximů, antidot organofosforových estrerázových inhibitorů
Czech description
Byla vyvinuta a v článku je popsána TLC metodika pro kvarterní inhibitory acetylcholinesterázy.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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