Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001809" target="_blank" >RIV/60162694:G44__/07:00001809 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications

Original language description

Cyclosarin is one member of nerve agents´ family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the

Czech name

Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace

Czech description

Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Relationship between structure of acetylcholinesterase reactivators and their reactivation potency</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Pharmaceutical Design

ISSN

1381-6128

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

33

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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