Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002130" target="_blank" >RIV/60162694:G44__/09:00002130 - isvavai.cz</a>

Alternative codes found

RIV/44555601:13440/09:00004893

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX

Original language description

The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) inplasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurotoxicity Research

ISSN

1029-8428

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

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UT code for WoS article

000271028000002

EID of the result in the Scopus database

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