Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50004539" target="_blank" >RIV/62690094:18470/15:50004539 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/15:43875536 RIV/00179906:_____/15:10320677

Result on the web

<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00065-8" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-800159-2.00065-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00065-8" target="_blank" >10.1016/B978-0-12-800159-2.00065-8</a>

Result language

angličtina

Original language name

Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Original language description

Nerve agents are organophosphorus compounds influencing cholinergic nerve transmission via inhibition of acetylcholinesterase (AChE; EC 3.1.1.7). The symptoms of intoxication include nicotinic, muscarinic, and central symptoms. Cholinesterases (ChEs; AChE and butyrylcholinesterase [BChE] EC 3.1.1.8) are characterized as the main enzymes involved in the toxic effect of these compounds including molecular forms. The activity of both enzymes is influenced by inhibitors and other factors such as their pathological states. The determination of ChEs is a key diagnostic tool in the diagnosis of poisoning with ChE inhibitors (OPs, nerve agents, and carbamates). For nerve agent intoxication, AChE in red blood cells is more diagnostically important than BChE activity in plasma. There are several methods for ChE determination; however, the most frequent is the Ellman's method and its modifications based on the hydrolysis of thiocholine esters and after detection of the free SH-group of the releas

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

KA - Militarism

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Handbook of toxicology of chemical warfare agents

ISBN

978-0-12-800159-2

Number of pages of the result

10

Pages from-to

967-976

Number of pages of the book

1184

Publisher name

Elsevier

Place of publication

Amsterdam

UT code for WoS chapter

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