Comparison of immunogenicity and safety between two paediatric TBE vaccines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002349" target="_blank" >RIV/60162694:G44__/10:00002349 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Comparison of immunogenicity and safety between two paediatric TBE vaccines

Original language description

TBE vaccination strategies capable of inducing strong paediatric immunogenicity and acceptable reactogenicity are still under evaluation. This study compared the immunogenicity and safety of the two paediatric TBE vaccines available in Europe (FSME-IMMUN(R) Junior and Encepur (R) Children) following administration of two doses of either vaccine in 303 children aged 1-11 years. Regardless of immunological test or viral antigen used, immunological responses were consistently higher in children vaccinatedwith FSME-IMMUN (R) Junior than those vaccinated with Encepur (R) Children. FSME-IMMUN (R) Junior is also non-inferior to Encepur (R) Children, with respect to NT seropositivity rates (p < 0.0001). Systemic reaction rates were low and similar between the vaccines. However, among children aged 7-11 years, local reactions were significantly higher after the first (p < 0.01) and second (p < 0.001) vaccination with Encepur (R) Children than with FSME-IMMUN (R) Junior, affecting half the chi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vaccine

ISSN

0264-410X

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

29

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

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UT code for WoS article

000279863900022

EID of the result in the Scopus database

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