Crohn's disease activity versus extent of DNA damage/repair and variability in the rage gene

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002362" target="_blank" >RIV/60162694:G44__/10:00002362 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/10:00040533

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Crohn's disease activity versus extent of DNA damage/repair and variability in the rage gene

Original language description

The aim of the study was to investigate the relationships between the extent of oxidative stress and DNA damage/repair, disease severity, and selected genetic variants in the RAGE gene in Crohn's disease (CD) patients. The study comprised a total of 46 subjects with CD and 99 control subjects. Disease activity was characterised by the Crohn's Disease Activity Index (CDAI) and paediatric CDAI (PCDAI) and complications requiring surgery (abscess, fistula or stenosis). Selected markers of oxidative stress(superoxide dismutase (Ery-SOD), glutathione peroxidase (WB-GPx), total plasma antioxidant capacity (P-tAOC), reduced glutathione (Ery-GSH) and malondialdehyde (P-MDA)), DNA damage (DNA single-strand breaks), and repair capacity detected (DNArc) by Cometassay were ascertained. Four SNPs in the RAGE gene were detected by PCR. A significant correlation between CD duration and DNArc was identified in adult patients (r = 0.44, P = 0.039), and adult CD subjects had significantly higher Ery-S

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

<a href="/en/project/KJB501620601" target="_blank" >KJB501620601: Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scripta medica Facultatis medicae Universitatis Brunensis Masarykianae

ISSN

1211-3395

e-ISSN

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Volume of the periodical

83

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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