The Relationship Between Serum Bilirubin and Crohn's Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282166" target="_blank" >RIV/00216208:11110/14:10282166 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10282166 RIV/00216208:11160/14:10282166 RIV/00064203:_____/14:10282166
Result on the web
<a href="http://journals.lww.com/ibdjournal/Fulltext/2014/03000/The_Relationship_Between_Serum_Bilirubin_and.7.aspx" target="_blank" >http://journals.lww.com/ibdjournal/Fulltext/2014/03000/The_Relationship_Between_Serum_Bilirubin_and.7.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/01.MIB.0000440817.84251.98" target="_blank" >10.1097/01.MIB.0000440817.84251.98</a>
Alternative languages
Result language
angličtina
Original language name
The Relationship Between Serum Bilirubin and Crohn's Disease
Original language description
Background: The oxidative stress is thought to play an important role in Crohn's disease (CD). As serum bilirubin represents the major endogenous antioxidant, this article aimed to evaluate in a clinical study, whether serum bilirubin levels and genes affecting its systemic concentrations are associated with CD. Methods: This exploratory case-control study was based on pediatric (n = 119) and adult (n = 504) patients with CD and 370 appropriate healthy control subjects. The (GT)(n) and (TA)(n) dinucleotide variations in heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) gene promoters were determined by fragment analysis. Serum bilirubin levels were compared in a subset of 90 cases and 229 controls, for whom biochemical data were available. Results: Substantially lower serum bilirubin levels were detected in patients with CD compared with controls (7.4 versus 12.1 mu mol/L, P < 10(-6)). Serum bilirubin levels were significantly lower in patients with CD within
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inflammatory Bowel Diseases
ISSN
1078-0998
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
481-487
UT code for WoS article
000335650700007
EID of the result in the Scopus database
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