Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002373" target="_blank" >RIV/60162694:G44__/10:00002373 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41330/10:49611 RIV/00216208:11160/10:00300580
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase
Original language description
Butyrylcholinesterase is considered to be an endogenous stoichiometric bioscavenger of organophosphorus compounds (OPs), but due to limited concentration of BChE in the organism, stoichiometric reduction of OP is not always sufficient. This can be improved by creating a pseudo-catalytic scavenger adding oximes as reactivators of inhibited exogenous BChE. On order to improve the BChE scavenging function in tabun and paraoxon poisoning, in vitro reactivation of phosphorylated human plasma BChE by bispyridinium oximes was studied, and some SAR were derived.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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