Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002445" target="_blank" >RIV/60162694:G44__/11:00002445 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/09553002.2011.548437" target="_blank" >http://dx.doi.org/10.3109/09553002.2011.548437</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo
Original language description
The large white pig is a useful experimental model to compare in vivo, in vitro and ex vivo sensitivity of peripheral blood leukocytes to ionizing radiation. We analysed dose- and time-dependent changes of lymphocyte and granulocyte absolute numbers. A flow cytometer were used to determine major leukocyte subpopulation numbers in blood samples after red cell removal. Similar to other species, lymphocyte numbers significantly decreased in pigs both in vivo and in vitro in a dose-dependent manner. Our data clearly show that reduction of lymphocyte numbers after irradiation in vivo proceeds much faster than after irradiation in vitro and that granulocyte changes depend only on the time of analysis after irradiation. All experimental arrangements demonstrated the radiosensitivity of lymphocytes and the radioresistance of peripheral blood granulocytes. These in vivo and in vitro approaches, as well as the newly introduced ex vivo observations, appear to be relevant to biodosimetry.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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