HI-6 and obidoxime implication in oxidative stress, antioxidants level and apoptosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002514" target="_blank" >RIV/60162694:G44__/11:00002514 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/11:43870283
Result on the web
<a href="http://www.academicjournals.org/ajpp/PDF/pdf2011/Aug/Pohanka%20et%20al.pdf" target="_blank" >http://www.academicjournals.org/ajpp/PDF/pdf2011/Aug/Pohanka%20et%20al.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
HI-6 and obidoxime implication in oxidative stress, antioxidants level and apoptosis
Original language description
The oxime reactivators, obidoxime and asoxime (HI-6) are suitable for antidotal treatment after exposure to nerve agents. Although they are considered for use in humans under emergency situations, complete clinical studies are lacking as there were no clinical trials. We examined obidoxime and HI-6 in laboratory rats intramuscularly exposed to 25% of the median lethal dose (210 and 780 mg/kg) of each oxime reactivator and sacrificed 40 min after exposure. Brain and liver ferric reducing antioxidant power, reduced glutathione (GSH), glutathione reductase, thiobarbituric acid reactive substances, acetylcholinesterase, caspase 3 and glutathione S-transferase were assessed using standard protocols. We found significant depletion of liver and brain low molecular weight antioxidants. On the other hand, the depletion was partially recovered by an increase in the GSH level. Obidoxime was implicated in alteration of apoptotic processes in brain. Overall effects of oxime reactivators are discuss
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/OVUOFVZ200905" target="_blank" >OVUOFVZ200905: Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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