Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874971" target="_blank" >RIV/60162694:G44__/13:43874971 - isvavai.cz</a>

Result on the web

<a href="http://academicjournals.org/journal/AJPP/article-abstract/068711B26356" target="_blank" >http://academicjournals.org/journal/AJPP/article-abstract/068711B26356</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5897/AJPP12.438" target="_blank" >10.5897/AJPP12.438</a>

Result language

angličtina

Original language name

Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety

Original language description

Obidoxime and asoxime (HI-6) are considered to be the most important acetylcholinesterase (AChE) reactivators applicable for treatment of poisoning by nerve agents. Unfortunately, toxicology of the oximes is not well known. For this reason, we decided toinvestigate the pertinent adverse effects on guinea pigs which are close to humans in toxicological point of view. HI-6 and obidoxime were administered intramuscularly in 5% of the median lethal dose. The animals were sacrificed 15, 30, 60, 120, and 240min after exposure, and the brain, liver, spleen and kidneys were collected. Ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), glutathione S-transferase (GST) and glutathione reductase (GR) were measured. Resultsindicated that obidoxime acted on oxidative stress than HI-6. We found evidence of low molecular weight antioxidants depletion after obidoxime administration. On the other hand, TBARS assay showed significant decrease in brain and little

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

African Journal of Pharmacy and Pharmacology

ISSN

1996-0816

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

31

Country of publishing house

NG - NIGERIA

Number of pages

6

Pages from-to

2252-2257

UT code for WoS article

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EID of the result in the Scopus database

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