Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874619" target="_blank" >RIV/60162694:G44__/12:43874619 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/ijms13022219" target="_blank" >http://dx.doi.org/10.3390/ijms13022219</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms13022219" target="_blank" >10.3390/ijms13022219</a>

Result language

angličtina

Original language name

Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology

Original language description

Alpha7 nicotinic acetylcholine receptor (alfa7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alfa7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alfa7 nAChR are suitable for treatment of multiplecognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779are representative examples of the novel compounds with affinity toward the alfa7 nAChR. Pharmacological, toxicological, and medicinal significance of alfa7 nAChR are discussed throughout this paper.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

19

Pages from-to

2219-2238

UT code for WoS article

000300715700060

EID of the result in the Scopus database

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