Pharmacological influencing of the cholinergic anti-inflammatory pathway in infectious diseases and inflammatory pathologies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F21%3A00556844" target="_blank" >RIV/60162694:G44__/21:00556844 - isvavai.cz</a>
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/33208075/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/33208075/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389557520666201117111715" target="_blank" >10.2174/1389557520666201117111715</a>
Alternative languages
Result language
angličtina
Original language name
Pharmacological influencing of the cholinergic anti-inflammatory pathway in infectious diseases and inflammatory pathologies
Original language description
The cholinergic anti-inflammatory pathway is a part of the parasympathetic nervous system and it can also be entitled as an anti-inflammatory reflex. It consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (AChE) terminating the neurotransmission. Stopping of inflammatory cytokines production is the major task for the cholinergic anti-inflammatory pathway. The cholinergic anti-inflammatory pathway can be stimulated or suppressed by agonizing or antagonizing alpha 7 nAChR or by inhibition of AChE. This review is focused on cholinergic anti-inflammatory pathway regulation by drugs. Compounds that inhibit cholinesterases (for instance, huperzine, rivastigmine, galantamine), and their impact on the cholinergic anti-inflammatory pathway are discussed here and a survey of actual literature is provided.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mini-Reviews in Medicinal Chemistry
ISSN
1389-5575
e-ISSN
1875-5607
Volume of the periodical
21
Issue of the periodical within the volume
6
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
10
Pages from-to
660-669
UT code for WoS article
000620347300001
EID of the result in the Scopus database
2-s2.0-85101239318