Cholinergic Anti-inflammatory Pathway and Stroke
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F17%3A00067522" target="_blank" >RIV/65269705:_____/17:00067522 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00095205
Result on the web
<a href="http://dx.doi.org/10.2174/1567201814666170201150015" target="_blank" >http://dx.doi.org/10.2174/1567201814666170201150015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1567201814666170201150015" target="_blank" >10.2174/1567201814666170201150015</a>
Alternative languages
Result language
angličtina
Original language name
Cholinergic Anti-inflammatory Pathway and Stroke
Original language description
Background: Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Methods: Research articles related to cholinergic anti-inflammatory pathway (CHAIP) and stroke were reviewed. The first part of review describes the basic characteristics of inflammatory response after stroke, main components and function of CHAIP. The second part reviews studies focused on CHAIP as a therapeutic target for ischemic and hemorrhagic stroke. Both pharmacological stimulation of alpha 7 nAChR and vagus nerve stimulation after stroke are reviewed. Results: Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) are the main components of CHAIP. Conclusion: Targeting cholinergic anti-inflammatory pathway is a promising way of immunomodulation which attenuates inflammation in a complex manner without causing immunosuppression.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GP14-23773P" target="_blank" >GP14-23773P: Regulation of inflammatory response by microRNAs in experimental model of subarachnoid hemorrhage</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Drug Delivery
ISSN
1567-2018
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
449-457
UT code for WoS article
000405313200002
EID of the result in the Scopus database
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