Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00052148" target="_blank" >RIV/00216224:14110/11:00052148 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/11:00002507 RIV/62157124:16270/11:43870663

Result on the web

<a href="http://dx.doi.org/10.2174/092986711794480140" target="_blank" >http://dx.doi.org/10.2174/092986711794480140</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/092986711794480140" target="_blank" >10.2174/092986711794480140</a>

Result language

angličtina

Original language name

Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway

Original language description

Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP) associated with the nicotinic acetylcholine receptor (nAChR) and the parasympathetic nervous system. The current pharmacological effectiveness in suppressing the inflammation in general and the septic shock in particular, is limited. CAP was discovered recently and it seems to be a suitable target for the development of new drugs. Moreover, available drugs binding to either nAChR or acetylcholinesterase(AChE) are candidates for either an inhibition or enhancement of CAP.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Medicinal Chemistry

ISSN

0929-8673

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

4

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

13

Pages from-to

539-551

UT code for WoS article

000287301000005

EID of the result in the Scopus database

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