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Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00052148" target="_blank" >RIV/00216224:14110/11:00052148 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/11:00002507 RIV/62157124:16270/11:43870663

  • Result on the web

    <a href="http://dx.doi.org/10.2174/092986711794480140" target="_blank" >http://dx.doi.org/10.2174/092986711794480140</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/092986711794480140" target="_blank" >10.2174/092986711794480140</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway

  • Original language description

    Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP) associated with the nicotinic acetylcholine receptor (nAChR) and the parasympathetic nervous system. The current pharmacological effectiveness in suppressing the inflammation in general and the septic shock in particular, is limited. CAP was discovered recently and it seems to be a suitable target for the development of new drugs. Moreover, available drugs binding to either nAChR or acetylcholinesterase(AChE) are candidates for either an inhibition or enhancement of CAP.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FN - Epidemiology, infection diseases and clinical immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Medicinal Chemistry

  • ISSN

    0929-8673

  • e-ISSN

  • Volume of the periodical

    18

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    13

  • Pages from-to

    539-551

  • UT code for WoS article

    000287301000005

  • EID of the result in the Scopus database