Macrophage-assisted inflamation and pharmacological regulation of the cholinergic anti-inflamatory pathway

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001523" target="_blank" >RIV/65269705:_____/11:#0001523 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/092986711794480140" target="_blank" >http://dx.doi.org/10.2174/092986711794480140</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/092986711794480140" target="_blank" >10.2174/092986711794480140</a>

Result language
angličtina
Original language name
Macrophage-assisted inflamation and pharmacological regulation of the cholinergic anti-inflamatory pathway
Original language description
Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP) associated with the nicotinic acetylcholine receptor (nAChR) and the parasympathetic nervous system. The current pharmacological effectiveness in suppressing the inflammation in general and the septic shock in particular, is limited. CAP was discovered recently and it seems to be a suitable target for the development of new drugs. Moreover, available drugs binding to either nAChR or acetylcholinesterase(AChE) are candidates for either an inhibition or enhancement of CAP. Though the current scientific databases do not include all necessary data on the association of CAP with body functions and the research is quite intensive, the object
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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