Acute toxicity of surfactants and detergend-based decontaminants in mice and rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874672" target="_blank" >RIV/60162694:G44__/12:43874672 - isvavai.cz</a>
Result on the web
<a href="http://mmsl.cz/viCMS/soubory/pdf/MMSL_2012_4_3_WWW.pdf" target="_blank" >http://mmsl.cz/viCMS/soubory/pdf/MMSL_2012_4_3_WWW.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Acute toxicity of surfactants and detergend-based decontaminants in mice and rats
Original language description
Detergent-based mixtures and pure surfactants used as decontaminants in mass casualty scenarios were investigated for their acute 24 h toxicity. Commercial detergents NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM were tested in male Wistar rats afterpercutaneous, peroral and intramuscular administration. Pure surfactants althosan MB, sodium alkylbenzene sulphonate, triton X, benzyl dimethyl dodecyl ammonium chloride, and N-dodecyl pyridinium bromide were investigated in male ICR mice. Estimated LD50 of surfactants varied from < 100 mg.kg-1 (i.m.) to more than 2000 mg.kg-1 (p.o, p.c.) in mice. All detergents tested in rats were rather less toxic (LD50 > 6 ml.kg-1), thus could be considered as safe if used as external skin decontaminant or if low volume is accidentally ingested.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/OVUOFVZ200803" target="_blank" >OVUOFVZ200803: Development of novel decontaminants and disinfectants of skin based on micellar compounds</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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