Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874690" target="_blank" >RIV/60162694:G44__/12:43874690 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/12:10124868
Result on the web
<a href="http://www.zsf.jcu.cz/jab/10_1/vavrova10_1.htm" target="_blank" >http://www.zsf.jcu.cz/jab/10_1/vavrova10_1.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/v10136-012-0002-2" target="_blank" >10.2478/v10136-012-0002-2</a>
Alternative languages
Result language
angličtina
Original language name
Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents
Original language description
Radiation therapy occupies an important position in the treatment of malignant diseases in spite of the existence of radiation side effects on normal tissues. Thus, substances are being developed which are designed to reduce both the acute and long termradiation effects on healthy tissues. Currently a sulphur-containing compound amifostine (WR2721, ethyol) is used in clinical practice as a radioprotectant. However, it itself has considerable side effects including hypotension (found in 62% of patients), hypocalcaemia, diarrhoea, nausea, and vomiting. Carbon nanospheres, known as fullerenes, and their water soluble derivatives (e.g. C-60(OH)(24), dendrofullerene DF-1) exert anti-oxidative properties and reduce damage to the DNA in irradiated cells. Water soluble fullerenes are low-toxic substances and thus, are attractive in terms of their use as radioprotectants.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OVUOFVZ200806" target="_blank" >OVUOFVZ200806: Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Biomedicine - print
ISSN
1214-021X
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
1-8
UT code for WoS article
000300403600001
EID of the result in the Scopus database
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