C60 Fullerene Derivative: Radioprotectiva Properties and a Toxicity Test in Vivo and in Vitro

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70565813%3A_____%2F12%3A%230000289" target="_blank" >RIV/70565813:_____/12:#0000289 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
C60 Fullerene Derivative: Radioprotectiva Properties and a Toxicity Test in Vivo and in Vitro
Original language description
The scope of use fullerenes and their derivatives, thank to their material and bonding properties, is increasing, including their application in biological system. The possibility of their use as substances affecting to the effect of ioninising radiationwas examined experimentally in vivo individual of Danio rerio in jeveline age )2,5 months) without differentiated sex and in vitro in tissue cultures in primoculture of guinea pig kidney cells and in melanoma cells B16-F10, parallelto the toxicty test. in order to achieve the accessibility of fullerenes for living organisms the reaction of C60 fullerene with peracetigacid and followed by hydrolysis of oxo-fullerene prapared in water-soluble fullerene derivative characterised by its Fourrier transformation infra-red spectrum (FTIR), and in its solution at a concentration of 147mg/L individuals of the jevenile form of Danio rerio can survive for a long time without sings of toxic effect. A radioprotective effect was showen in fish after t
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/VG20102014049" target="_blank" >VG20102014049: Research of the possibilities for application of a new materials (focusing on nano-materials) and advanced technologies for protection of people against the exposure to CBRN materials, with emphasis on critical infrastructure</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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