Five experimental bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from azinphos-methyl-induced toxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874862" target="_blank" >RIV/60162694:G44__/13:43874862 - isvavai.cz</a>
Result on the web
<a href="http://www.stmconnect.com/sites/default/files/44-50%20%20JEIT-D-12-00009.pdf" target="_blank" >http://www.stmconnect.com/sites/default/files/44-50%20%20JEIT-D-12-00009.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7178/jeit.14" target="_blank" >10.7178/jeit.14</a>
Alternative languages
Result language
angličtina
Original language name
Five experimental bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from azinphos-methyl-induced toxicity
Original language description
In search of more efficacious treatment options for organophosphate poisoning, several experimental K-oximes have been synthesized, which display excellent in vitro efficacy in protecting acetylcholinesterase from inhibition by a broad variety of organophosphorus compounds. To test the efficacy of these K-oximes (K-27, K-48, K-53, K-74, K-75) in vivo, the extent of oxime-conferred protection from mortality induced by the organophosphate pesticide azinphos-methyl was quantified by Cox survival analysis and compared with that of the clinically available oximes pralidoxime and obidoxime. Rats received azinphos-methyl, which is hepatically converted to the active oxon form, in a dosage of 5, 10 or 15 mýmol, and immediately thereafter intraperitoneal injections of the respective oxime at a dosage of half the LD01. K-53 reduced the relative risk of death (RR) to 0.22 (controls: RR=1; pLESS-THAN OR EQUAL TO0.05), which was significantly (pLESS-THAN OR EQUAL TO0.05) better than obidoxime (RR=0
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
KA - Militarism
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Environmental Immunology and Toxicology
ISSN
2225-1219
e-ISSN
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Volume of the periodical
1
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
44-50
UT code for WoS article
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EID of the result in the Scopus database
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