DNA-dependent protein kinase and its inhibition in support of radiotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874893" target="_blank" >RIV/60162694:G44__/13:43874893 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00394806
Result on the web
<a href="http://dx.doi.org/10.3109/09553002.2013.767993" target="_blank" >http://dx.doi.org/10.3109/09553002.2013.767993</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/09553002.2013.767993" target="_blank" >10.3109/09553002.2013.767993</a>
Alternative languages
Result language
angličtina
Original language name
DNA-dependent protein kinase and its inhibition in support of radiotherapy
Original language description
PURPOSE: Radiotherapy has been used as a treatment of almost 50% of all malignant tumors. The aim of this review is to provide a comprehensive overview of the recent knowledge in the field of molecular mechanisms of radiation-induced double-stranded breaks (DSB) repair. This paper gives particular emphasis to a key DNA repair enzyme, DNA-dependent protein kinase (DNA-PK), which plays a pivotal role in non-homologous end-joining. Furthermore, we discuss possibilities of DNA-PK inhibition and other molecular approaches employed in order to facilitate radiotherapy. CONCLUSIONS: We have reviewed the recent studies using novel potent and selective small-molecular DNA-PK inhibitors and we conclude that targeted inhibition of DNA repair proteins like DNA-PK in cancer cells, in combination with ionizing radiation, improves the efficacy of cancer therapy while minimizing side-effects of ionizing radiation. Moreover, the recent discovery of short interfering RNA (siRNA) and signal interfering DN
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Radiation Biology
ISSN
0955-3002
e-ISSN
—
Volume of the periodical
89
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
416-423
UT code for WoS article
000319747500004
EID of the result in the Scopus database
—