Caffeine inhibits acetylcholinesterase but not butyrylcholinesterase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874949" target="_blank" >RIV/60162694:G44__/13:43874949 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/13:#0000412
Result on the web
<a href="http://www.mdpi.com/1422-0067/14/5/9873" target="_blank" >http://www.mdpi.com/1422-0067/14/5/9873</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms14059873" target="_blank" >10.3390/ijms14059873</a>
Alternative languages
Result language
angličtina
Original language name
Caffeine inhibits acetylcholinesterase but not butyrylcholinesterase
Original language description
Caffeine is an alkaloid with a stimulant effect in the body. It can interfere in transmissions based on acetylcholine, epinephrine, norepinephrine, serotonin, dopamine and glutamate. Clinical studies indicate that it can be involved in the slowing of Alzheimer disease pathology and some other effects. The effects are not well understood. In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission. A standard Ellman test with human AChE and BChE was done for altering concentrations of caffeine. The test was supported by an in silico examination as well. Donepezil and tacrine were used as standards. In compliance with Dixon's plot, caffeine was proved to be a non-competitive inhibitor of AChE and BChE. However, inhibition of BChE was quite weak, as the inhibition constant, Ki, was 13.9 +- 7.4 mol/L. Inhibition of AChE was more relevant, as Ki w
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
9873-9882
UT code for WoS article
000319441500069
EID of the result in the Scopus database
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