Melatonin Changes tularemia progression in a BALB/c mouse model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874970" target="_blank" >RIV/60162694:G44__/13:43874970 - isvavai.cz</a>
Result on the web
<a href="http://academicjournals.org/journal/AJPP/article-abstract/8DFD30227327" target="_blank" >http://academicjournals.org/journal/AJPP/article-abstract/8DFD30227327</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5897/AJPP2013.3496" target="_blank" >10.5897/AJPP2013.3496</a>
Alternative languages
Result language
angličtina
Original language name
Melatonin Changes tularemia progression in a BALB/c mouse model
Original language description
Melatonin is a hormone with antioxidant properties. In the body, melatonin is involved in regulation of circadian biological rhythm. However, receptors for melatonin are expressed on disparate organs and they can be found on immune cells as well. The present experiment is focused on research whether melatonin would regulate pathogenesis caused by a model intracellular pathogen, Francisella tularensis. For the reason, laboratory mice BALB/c were infected with F. tularensis. Melatonin was given in two doses: 10 and 100 ?g/kg. Animals were sacrificed after either three or five days. Spleen and liver were sampled for bacterial burden. Interferon gamma (IFN-gama), interleukin 2 (IL-2) and total immunoglobulins were assayed from plasma samples. We proved that melatonin is able to reduce bacterial burden in the organs in a dose response manner. Surprisingly, IFN-gama and IL-2 levels were reduced as well. Immunoglobulins remained unchanged. We conclude our experiment that melatonin is potent t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
African Journal of Pharmacy and Pharmacology
ISSN
1996-0816
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
27
Country of publishing house
NG - NIGERIA
Number of pages
7
Pages from-to
1917-1923
UT code for WoS article
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EID of the result in the Scopus database
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