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Melatonin Changes tularemia progression in a BALB/c mouse model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874970" target="_blank" >RIV/60162694:G44__/13:43874970 - isvavai.cz</a>

  • Result on the web

    <a href="http://academicjournals.org/journal/AJPP/article-abstract/8DFD30227327" target="_blank" >http://academicjournals.org/journal/AJPP/article-abstract/8DFD30227327</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5897/AJPP2013.3496" target="_blank" >10.5897/AJPP2013.3496</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Melatonin Changes tularemia progression in a BALB/c mouse model

  • Original language description

    Melatonin is a hormone with antioxidant properties. In the body, melatonin is involved in regulation of circadian biological rhythm. However, receptors for melatonin are expressed on disparate organs and they can be found on immune cells as well. The present experiment is focused on research whether melatonin would regulate pathogenesis caused by a model intracellular pathogen, Francisella tularensis. For the reason, laboratory mice BALB/c were infected with F. tularensis. Melatonin was given in two doses: 10 and 100 ?g/kg. Animals were sacrificed after either three or five days. Spleen and liver were sampled for bacterial burden. Interferon gamma (IFN-gama), interleukin 2 (IL-2) and total immunoglobulins were assayed from plasma samples. We proved that melatonin is able to reduce bacterial burden in the organs in a dose response manner. Surprisingly, IFN-gama and IL-2 levels were reduced as well. Immunoglobulins remained unchanged. We conclude our experiment that melatonin is potent t

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    African Journal of Pharmacy and Pharmacology

  • ISSN

    1996-0816

  • e-ISSN

  • Volume of the periodical

    7

  • Issue of the periodical within the volume

    27

  • Country of publishing house

    NG - NIGERIA

  • Number of pages

    7

  • Pages from-to

    1917-1923

  • UT code for WoS article

  • EID of the result in the Scopus database