Impact of caffeine on tularemia progression in a mouse model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F15%3A43875483" target="_blank" >RIV/60162694:G44__/15:43875483 - isvavai.cz</a>
Result on the web
<a href="http://microbiologyjournal.org/jmabsarchive.php?vol=9&issue=2" target="_blank" >http://microbiologyjournal.org/jmabsarchive.php?vol=9&issue=2</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Impact of caffeine on tularemia progression in a mouse model
Original language description
Caffeine is an alkaloid acting as an antagonist on adenosine receptors; however, the other targets for caffeine are known as well.Not much is known about effect of caffeine on immunity. In this work, we have hypothesized that caffeine can cause alteration of infectious disease progression. Tularemia, a zoonotic disease caused by Francisellatularensis, was used as the model disease and BALB/c mice were used as an in vivo model. Interleukines (IL) 1b, 2, 4, 6 and interferon g (IFN-g) were assayed by enzyme linked immuno-sorbent assay (ELISA) from plasma and bacterial burden was tested in spleen. We proved that caffeine caused increase of bacterial burden in the spleen in dose response manner. Oppose to this, IL-6 and IFN-gwere decreased in dose response manner. Caffeine seems to be able to modulate tularemia progression. Impact on neutrophils via adenosine receptors and on macrophages via cholinergic anti-inflammatory pathway is the most probable explanation.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pure and Applied Microbiology
ISSN
0973-7510
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
2
Country of publishing house
IN - INDIA
Number of pages
6
Pages from-to
913-918
UT code for WoS article
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EID of the result in the Scopus database
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