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Impact of caffeine on tularemia progression in a mouse model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F15%3A43875483" target="_blank" >RIV/60162694:G44__/15:43875483 - isvavai.cz</a>

  • Result on the web

    <a href="http://microbiologyjournal.org/jmabsarchive.php?vol=9&issue=2" target="_blank" >http://microbiologyjournal.org/jmabsarchive.php?vol=9&issue=2</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Impact of caffeine on tularemia progression in a mouse model

  • Original language description

    Caffeine is an alkaloid acting as an antagonist on adenosine receptors; however, the other targets for caffeine are known as well.Not much is known about effect of caffeine on immunity. In this work, we have hypothesized that caffeine can cause alteration of infectious disease progression. Tularemia, a zoonotic disease caused by Francisellatularensis, was used as the model disease and BALB/c mice were used as an in vivo model. Interleukines (IL) 1b, 2, 4, 6 and interferon g (IFN-g) were assayed by enzyme linked immuno-sorbent assay (ELISA) from plasma and bacterial burden was tested in spleen. We proved that caffeine caused increase of bacterial burden in the spleen in dose response manner. Oppose to this, IL-6 and IFN-gwere decreased in dose response manner. Caffeine seems to be able to modulate tularemia progression. Impact on neutrophils via adenosine receptors and on macrophages via cholinergic anti-inflammatory pathway is the most probable explanation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Pure and Applied Microbiology

  • ISSN

    0973-7510

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    IN - INDIA

  • Number of pages

    6

  • Pages from-to

    913-918

  • UT code for WoS article

  • EID of the result in the Scopus database