Caffeine downregulates antibody production in a mouse model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F15%3A43875350" target="_blank" >RIV/60162694:G44__/15:43875350 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1214021X14000799" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X14000799</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2014.09.001" target="_blank" >10.1016/j.jab.2014.09.001</a>

Result language

angličtina

Original language name

Caffeine downregulates antibody production in a mouse model

Original language description

Caffeine is a secondary plant metabolite found in coffee and tea. Its major pathway is interaction with adenosine receptors. Minor pathways are also known. An effect of caffeine on immunity has been proposed. In this paper, the role of caffeine on the immune system was studied, using a BALB/c mouse model. The animals received saline (controls), keyhole limpet hemocyanin (KLH) 1 mg/kg or caffeine (alone or in combination with KLH) in doses of 1-16 mg/kg. The mice were sacrificed 1-7 days later and plasmalevels of interleukin (IL) 2, 4, 6, 10, 12 and antibodies against KLH were determined by enzyme linked immunosorbent assay (ELISA). Caffeine caused a significant decrease in KLH-stimulated antibody production. The effect was dose dependent. There were similar findings for IL-2 and IL-4 but not for IL-6, IL-10 and IL-12. The significance of the findings is discussed with extrapolation to humans based on caffeine doses used in the study and the amount of caffeine in available beverages.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

1-6

UT code for WoS article

000350670600001

EID of the result in the Scopus database

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