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Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875219" target="_blank" >RIV/60162694:G44__/14:43875219 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.nel.edu/archive_issues/o/35_s2/35_s2_Pohanka_155-157.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/35_s2/35_s2_Pohanka_155-157.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model

  • Original language description

    OBJECTIVES: HI-6 or asoxime in some sources is an antidotum for nerve agents. In recent experiments, implication of HI-6 in immunity response was proved; however, the issue was not studied in details. In this experiment, role of cytokines in HI-6 impacton immunity was searched. DESIGN: BALB/c mice were exposed to saline, HI-6 in a dose 1 - 100 mg/kg and/or 1 keyhole limpet hemocyanin (KLH) 1 mg/kg. Mice were sacrificed 21 days after experiment beginning and interleukins (IL) 1, 2, 4, 6 were determinedby Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: The animals had no pathological manifestation. From the tested cytokines, no significant alteration was found for the IL-1, IL-4 and IL-6. IL-2 was significantly increased in a dose response manner.CONCLUSIONS: The experimental data well correlates with the previous work where HI-6 caused increase of antibodies production. HI-6 is suitable to be used as an adjuvant whenever immunity should be pharmacologically altered.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neuroendocrinology Letters

  • ISSN

    0172-780X

  • e-ISSN

  • Volume of the periodical

    35

  • Issue of the periodical within the volume

    Suppl 2

  • Country of publishing house

    SE - SWEDEN

  • Number of pages

    3

  • Pages from-to

    155-157

  • UT code for WoS article

    000351064900020

  • EID of the result in the Scopus database