Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875219" target="_blank" >RIV/60162694:G44__/14:43875219 - isvavai.cz</a>
Result on the web
<a href="http://www.nel.edu/archive_issues/o/35_s2/35_s2_Pohanka_155-157.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/35_s2/35_s2_Pohanka_155-157.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model
Original language description
OBJECTIVES: HI-6 or asoxime in some sources is an antidotum for nerve agents. In recent experiments, implication of HI-6 in immunity response was proved; however, the issue was not studied in details. In this experiment, role of cytokines in HI-6 impacton immunity was searched. DESIGN: BALB/c mice were exposed to saline, HI-6 in a dose 1 - 100 mg/kg and/or 1 keyhole limpet hemocyanin (KLH) 1 mg/kg. Mice were sacrificed 21 days after experiment beginning and interleukins (IL) 1, 2, 4, 6 were determinedby Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: The animals had no pathological manifestation. From the tested cytokines, no significant alteration was found for the IL-1, IL-4 and IL-6. IL-2 was significantly increased in a dose response manner.CONCLUSIONS: The experimental data well correlates with the previous work where HI-6 caused increase of antibodies production. HI-6 is suitable to be used as an adjuvant whenever immunity should be pharmacologically altered.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroendocrinology Letters
ISSN
0172-780X
e-ISSN
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Volume of the periodical
35
Issue of the periodical within the volume
Suppl 2
Country of publishing house
SE - SWEDEN
Number of pages
3
Pages from-to
155-157
UT code for WoS article
000351064900020
EID of the result in the Scopus database
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