Tacrine can suppress immunity response to tularemia in BALB/c mouse model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874947" target="_blank" >RIV/60162694:G44__/13:43874947 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1214021X14600892?via=ihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X14600892?via=ihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/v10136-012-0021-z" target="_blank" >10.2478/v10136-012-0021-z</a>

Result language
angličtina
Original language name
Tacrine can suppress immunity response to tularemia in BALB/c mouse model
Original language description
Tacrine is an inhibitor of enzyme acetylcholinesterase (AChE). In the past, it was used for the treatment of cognitive dysfunction during vascular dementia and Alzheimer disease. Some works have concluded that AChE inhibitors can modulate immune response, and for this reason, we decided to investigate the immune response to a model bacterial disease - tularemia - for which both innate and specific immunity are necessary to resolve the disease. We used 64 BALB/c mice divided into eight groups exposed variously to saline, tacrine in a dose of 20.0-500 mu g/kg, infection with tularemia and infection with the contemporary application of tacrine. The mice were euthanized three days after the start of the experiment. We proved a significant reduction in thelevels of interleukin-6 (IL-6) and interferon gamma (IFN-gamma) in a dose response manner in the infected animals in the course of tularemia. Moreover, tacrine caused a significant increase of the bacterial burden in the liver and spleen.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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