Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F12%3A43871483" target="_blank" >RIV/62157124:16270/12:43871483 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/v10102-012-0004-7" target="_blank" >http://dx.doi.org/10.2478/v10102-012-0004-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/v10102-012-0004-7" target="_blank" >10.2478/v10102-012-0004-7</a>

Result language
angličtina
Original language name
Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice
Original language description
The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with Francisella tularensis and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected miceexposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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