Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in mice BALB/c

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874634" target="_blank" >RIV/60162694:G44__/12:43874634 - isvavai.cz</a>

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Acetylcholine%20and%20an%20acetylcholinesterase%20inhibitor%20neostigmine%20can%20aggravate%20tularemia%20progress%20in%20mice%20BALB%2Fc" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed?term=Acetylcholine%20and%20an%20acetylcholinesterase%20inhibitor%20neostigmine%20can%20aggravate%20tularemia%20progress%20in%20mice%20BALB%2Fc</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10102-012-0004-7" target="_blank" >10.2478/v10102-012-0004-7</a>

Result language

angličtina

Original language name

Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in mice BALB/c

Original language description

The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with Franciselle tularensis and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected miceexposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Interdisciplinary Toxicology

ISSN

1337-6853

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

4

Pages from-to

21-24

UT code for WoS article

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EID of the result in the Scopus database

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