Neostigmine modulates tularemia progression in BALB/c mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874628" target="_blank" >RIV/60162694:G44__/12:43874628 - isvavai.cz</a>
Result on the web
<a href="http://www.academicjournals.org/AJPP" target="_blank" >http://www.academicjournals.org/AJPP</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5897/AJPP12.065" target="_blank" >10.5897/AJPP12.065</a>
Alternative languages
Result language
angličtina
Original language name
Neostigmine modulates tularemia progression in BALB/c mice
Original language description
Neostigmine is a pseudo-irreversible inhibitor of enzyme acetylcholinesterase (AChE). We hypothesized link between neostigmine and cholinergic anti-inflammatory pathway via better availability of blood acetylcholine after AChE inhibition and consequent activation of nicotinic acetylcholine receptors. Owing to the expected mechanism of action, we expect significant impact of neostigmine on immunity. In the reported experiment, we used BALB/c mouse model and experimental infection with Francisella tularensis, a causative agent of tularemia. Interferon., interleukin 6 and mortality test are done for neostigmine doses of 8.00, 40.0 and 200 mu g/kg. We proved significant decrease of both cytokines in course of neostigmine in a dose dependent manner. Neostigmine aggravates mortality caused by tularemia. Owing to the reported results, application of AChE inhibitors to patients suspected with tularemia or similar diseases can be considered as a life endangering therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
African Journal of Pharmacy and Pharmacology
ISSN
1996-0816
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
17
Country of publishing house
NG - NIGERIA
Number of pages
6
Pages from-to
1317-1322
UT code for WoS article
000307940400003
EID of the result in the Scopus database
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