Tacrine alters antibodies level in Francisella tularensis-infected mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F13%3A43872269" target="_blank" >RIV/62157124:16270/13:43872269 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/13:43874967

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tacrine alters antibodies level in Francisella tularensis-infected mice

Original language description

Tacrine is an inhibitor of acetylcholinestrase (AChE) formerly used to treat cognitive impairment of Alzheimer disease. In previous works, we have shown that inhibitors of AChE can modulate innate immunity responses. In the present study we focused on modulation of adaptive immunity represented by production of antibodies. It is hypothesized that the cholinergic anti-inflammatory pathway is a common mechanism how inhibitors of AChE can influence immunity. Here, tularemia is used as a model disease for experimental purposes. Tacrine significantly suppressed adaptive immunity represented by the ability of the organism to produce antibodies. We infer that tacrine can modulate the cholinergic anti-inflammatory pathway by a mechanism based on inhibition ofblood AChE followed by higher availability of acetylcholine. The anti-inflammatory pathway is then stimulated and the body is not able to simply resolve antigen. Application of an AChE inhibitor during infectious diseases can have detrime

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

134-137

UT code for WoS article

000330901000021

EID of the result in the Scopus database

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