Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875095" target="_blank" >RIV/60162694:G44__/14:43875095 - isvavai.cz</a>
Result on the web
<a href="http://www.mdpi.com/1422-0067/15/6/9809/htm" target="_blank" >http://www.mdpi.com/1422-0067/15/6/9809/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms15069809" target="_blank" >10.3390/ijms15069809</a>
Alternative languages
Result language
angličtina
Original language name
Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity
Original language description
Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer's disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a "cholinergic anti-inflammatory pathway" which raises questions about the role of these inhibitors in the immune system. This review covers research and discussion of the role of the inhibitors in modulating the immune response using as examples the commonly available drugs, donepezil, galantamine, huperzine, neostigmine and pyridostigmine. Major attention is given to the cholinergic anti-inflammatory pathway, a well-described link between the central nervous system and terminal effector cells in the immune system.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
9809-9825
UT code for WoS article
000338639000036
EID of the result in the Scopus database
—