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In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to aid discovery of potential, more efficacious novel non-oxime reactivators

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874977" target="_blank" >RIV/60162694:G44__/13:43874977 - isvavai.cz</a>

  • Alternative codes found

    RIV/62690094:18470/13:50001352

  • Result on the web

    <a href="http://benthamscience.com/journal/contents.php?journalID=ccadd&issueID=114807" target="_blank" >http://benthamscience.com/journal/contents.php?journalID=ccadd&issueID=114807</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/15734099113099990012" target="_blank" >10.2174/15734099113099990012</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to aid discovery of potential, more efficacious novel non-oxime reactivators

  • Original language description

    Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphorus (OP) nerve agent considered as potential warfare threats and known to be resistant to conventional oxime antidotal therapy. To aid discovery of novel antidotes for GF toxicity, a three-dimensional in silico pharmacophore model for reactivation efficacy against GF intoxication is presented. The model was generated from published experimental percentage reactivation data on oximes as changes of AChE/BuChE activities in the whole blood after cyclosarin intoxication and administration. The generated pharmacophore model was found to contain a hydrogen bond donor site and two ring aromatic sites as necessary optimal features for reactivation of GF intoxication.Stereo-electronic features of oximes reported by us earlier provided guidance to develop the model and were found to be consistent with the reported structure activity data. Furthermore, from virtual screening of two commercial databases

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Computer-Aided Drug Design

  • ISSN

    1573-4099

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    10

  • Pages from-to

    402-411

  • UT code for WoS article

    000323931600011

  • EID of the result in the Scopus database