Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874790" target="_blank" >RIV/60162694:G44__/13:43874790 - isvavai.cz</a>
Result on the web
<a href="http://www.stmconnect.com/sites/default/files/41-43%20%20JEIT-D-12-00014.pdf" target="_blank" >http://www.stmconnect.com/sites/default/files/41-43%20%20JEIT-D-12-00014.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7178/jeit.16" target="_blank" >10.7178/jeit.16</a>

Result language
angličtina
Original language name
Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents
Original language description
Cholinesterase reactivators are a group of drugs originally developed as antidotes for treatment of nerve agent intoxications. Although there are five commercially available members of this group, none is considered to be a universal solution for treatment of intoxication caused by all nerve agents. Due to this, novel drug candidates are searched. To find the most promising antidotes, structure activity studies are conducted. In this contribution, distance between quaternary nitrogen and aldoxime (called oxime) group responsible for the reactivation process is discussed. For this purpose, three structurally different oxime reactivators were tested for their potency to reactivate tabun, sarin, cyclosarin and VX agent-inhibited acetylcholinesterase (AC hE; EC 3.1.1.7). As resulted, only "standard" oxime reactivators with oxime group connected to the heteroaromatic ring could be considered as promising AC hE reactivators. Those with oxime group on other aromatic ring or those with quatern
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—

Project
<a href="/en/project/NT12062" target="_blank" >NT12062: Preparation and biological evaluation of new therapeutics against to pesticides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)