B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875161" target="_blank" >RIV/60162694:G44__/14:43875161 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0882401014001235" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0882401014001235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micpath.2014.08.009" target="_blank" >10.1016/j.micpath.2014.08.009</a>

Result language
angličtina
Original language name
B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection
Original language description
Francisella tularensis, a facultative intracellular Gram-negative bacterium, causes the illness tularemia. The infection of mice with live vaccine strain is considered to be a model of human tularemia. E tularensis infects predominantly such phagocytic cells as macrophages or neutrophils, but it also infects non-phagocytic hepatocytes, epithelial cells, and murine and human B cell lines. Based on work with the murine tularemia model, we report here that F. tularensis LVS infects peritoneal CD19(+) cells- exclusively B-la cells early after intraperitoneal infection in vivo. The peritoneal and consequently spleen CD19+ cells are activated by the F. tularensis LVS infection to express the activation markers from MHC class II, CD25, CD54, CD69, and the co-stimulatory molecules CD80 and CD86. As early as 12 h post-infection, the peritoneal CD19(+) cells produce IFN-gamma, IL-1 beta, IL-4, IL-6, IL-12, IL-17, IL-23, and THE-alpha. The spleen CD19(+) cells respond to infection with some dela
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/GAP302%2F11%2F1631" target="_blank" >GAP302/11/1631: The role of B cells during natural and adaptive phase of immune response against Francisella tularensis infection in mice</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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