Entry of Francisella tularensis into murine B cells: the role of B cell receptors and complement receptors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F15%3A43875407" target="_blank" >RIV/60162694:G44__/15:43875407 - isvavai.cz</a>

Result on the web

<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132571" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132571</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0132571" target="_blank" >10.1371/journal.pone.0132571</a>

Result language

angličtina

Original language name

Entry of Francisella tularensis into murine B cells: the role of B cell receptors and complement receptors

Original language description

Francisella tularensis, the etiological agent of tularemia, is an intracellular pathogen that dominantly infects and proliferates inside phagocytic cells but can be seen also in nonphagocytic cells, including B cells. Although protective immunity is known to be almost exclusively associated with the type 1 pathway of cellular immunity, a significant role of B cells in immune responses already has been demonstrated. Whether their role is associated with antibody-dependent or antibody-independent B cell functions is not yet fully understood. The character of early events during B cell-pathogen interaction may determine the type of B cell response regulating the induction of adaptive immunity. We used fluorescence microscopy and flow cytometry to identifythe basic requirements for the entry of F. tularensis into B cells within in vivo and in vitro infection models. Here, we present data showing that Francisella tularensis subsp. holarctica strain LVS significantly infects individual subs

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/GAP302%2F11%2F1631" target="_blank" >GAP302/11/1631: The role of B cells during natural and adaptive phase of immune response against Francisella tularensis infection in mice</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

21

Pages from-to

"Art"," Number: e0132571"

UT code for WoS article

000358162300154

EID of the result in the Scopus database

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