Francisella and Antibodies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F21%3A00557513" target="_blank" >RIV/60162694:G44__/21:00557513 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2076-2607/9/10/2136/pdf" target="_blank" >https://www.mdpi.com/2076-2607/9/10/2136/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/microorganisms9102136" target="_blank" >10.3390/microorganisms9102136</a>

Result language
angličtina
Original language name
Francisella and Antibodies
Original language description
Immune responses to intracellular pathogens depend largely upon the activation of T helper type 1-dependent mechanisms. The contribution of B cells to establishing protective immunity has long been underestimated. Francisella tularensis, including a number of subspecies, provides a suitable model for the study of immune responses against intracellular bacterial pathogens. We previously demonstrated that Francisella infects B cells and activates B-cell subtypes to produce a number of cytokines and express the activation markers. Recently, we documented the early production of natural antibodies as a consequence of Francisella infection in mice. Here, we summarize current knowledge on the innate and acquired humoral immune responses initiated by Francisella infection and their relationships with the immune defense systems.
Czech name
—
Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/VJ01030003" target="_blank" >VJ01030003: The Creation of Czech-Irish Project Cooperation for Solving the Biological Security Questions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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